Caspase 9 is an enzyme that in humans is encoded by the casp9 gene it is an initiator caspase critical to the apoptotic pathway found in many tissues. Parp 1 was originally identified as an apoptotic substrate for caspase 3 31 but more recent studies have shown that caspase 7 is also involved in the cleavage process 39. Second nifedipine a calcium channel blocker attenuated hg induced caspase 3 activation and lamin b degradation in islet β cells suggesting that calcium overload could be causal to hg induced nuclear alterations.
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